Wednesday, July 1, 2015

Do you have a protein to share with the world?

Did you know that you can submit protein sequences directly to UniProt to be included in our database? We accept protein sequences that have been determined at protein level (via Edman degradation or manual interpretation of tandem-mass spectrometry data) and have clear species identification.

The UniProt home page contains a link in the 'UniProt data' section' that says 'Submit your data'. This takes you to a UniProt help page about data submission.. Just follow the link for submitting protein sequences to get started! Submission is done using SPIN, a web-based tool where you can enter your protein sequence and any associated biological information. All of the information required to create a database entry will be collected during the submission process.

You can submit large batches of multiple sequences as well as individual sequences. A UniProt curator will then review your submission and create a reviewed (UniProtKB/Swiss-Prot) entry for each submitted sequence. Once your protein is inUniProtKB, it will be assigned a stable accession number which can be used in publications. Data can be kept confidential until publication.

Note that translations of coding sequences (CDS) submitted to the EMBL-Bank/GenBank/DDBJ nucleotide sequence resources are automatically transferred to the TrEMBL section of UniProtKB and do not need to be submitted to UniProtKB separately:

The direct submissions we get often include interesting proteins like toxins or anti-freeze proteins and sometimes even proteins from extinct organisms! For example, here's a fragment of a Neanderthal bone protein that we received as a direct submission

So if you would like to make your sequences accessible to other researchers, even if they are fragments, just send them in with their species and identification method. If you have any questions, please feel free to write to us at

1 comment:

  1. Some examples of protein hormones include growth hormone, which is produced by the pituitary gland, and follicle-stimulating rhythmic hormone replacement therapy (FSH), which has an attached carbohydrate group and is thus classified as a glycoprotein. FSH helps stimulate the maturation of eggs in the ovaries and sperm in the testes.